Data Integrity Assessment ALCOA+ Principles Checklist [FREE PDF]

This data integrity assessment alcoa+ principles checklist ensures compliance with FDA Data Integrity Guidance 2018 requirements. Data Integrity Officer / QAs use this checklist to verify regulatory compliance, document findings, and maintain safety and quality standards.

  • Industry: Pharmaceutical / Life Sciences
  • Frequency: Quarterly
  • Estimated Time: 3-4 hours
  • Role: Data Integrity Officer / QA
  • Total Items: 21
  • Compliance: FDA Data Integrity Guidance 2018, MHRA Data Integrity Guidance, WHO Technical Report Series 996, ICH Q10 Pharmaceutical Quality System

Documentation and Regulatory Review

Verify required documentation is current and complete.

  • Standard Operating Procedures (SOPs) current and accessible?
  • All personnel training records current for this activity?
  • Required permits, licenses, and registrations current?
  • Previous inspection findings reviewed and corrective actions verified?

Safety and Equipment Requirements

Verify safety equipment, PPE, and emergency preparations.

  • Required PPE available, clean, and in good condition?
  • Emergency equipment (eyewash, shower, extinguisher) accessible?
  • Safety Data Sheets (SDS) available for all hazardous materials?
  • Emergency contact and response procedures posted?

Operational Compliance Checks

Verify operations comply with regulatory requirements.

  • Approved procedures being followed without deviation?
  • Equipment qualified/calibrated and within calibration period?
  • Environmental monitoring (temp, humidity, pressure) within spec?
  • All materials, products, and containers properly labeled?
  • Data recorded contemporaneously with no unexplained alterations?

Waste Disposal and Environmental Compliance

Verify proper waste handling and disposal.

  • All waste properly labeled with contents and hazard class?
  • Waste containers appropriate for waste type and in good condition?
  • Waste streams segregated per regulatory requirements?
  • Waste disposal records maintained?

Findings and CAPA

Document findings and corrective/preventive actions.

  • Any deviations or non-conformances identified?
  • CAPA initiated for any findings?
  • Photo documentation of findings?
  • Inspection findings and recommendations

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Why Use This Data Integrity Assessment ALCOA+ Principles Checklist [FREE PDF]?

This data integrity assessment alcoa+ principles checklist [free pdf] helps pharmaceutical / life sciences teams maintain compliance and operational excellence. Designed for data integrity officer / qa professionals, this checklist covers 21 critical inspection points across 5 sections. Recommended frequency: quarterly.

Ensures compliance with FDA Data Integrity Guidance 2018, MHRA Data Integrity Guidance, WHO Technical Report Series 996, ICH Q10 Pharmaceutical Quality System. Regulatory-aligned for audit readiness and inspection documentation.

Frequently Asked Questions

What does the Data Integrity Assessment ALCOA+ Principles Checklist [FREE PDF] cover?

This checklist covers 21 inspection items across 5 sections: Documentation and Regulatory Review, Safety and Equipment Requirements, Operational Compliance Checks, Waste Disposal and Environmental Compliance, Findings and CAPA. It is designed for pharmaceutical / life sciences operations and compliance.

How often should this checklist be completed?

This checklist should be completed quarterly. Each completion takes approximately 3-4 hours.

Who should use this Data Integrity Assessment ALCOA+ Principles Checklist [FREE PDF]?

This checklist is designed for Data Integrity Officer / QA professionals in the pharmaceutical / life sciences industry. It can be used for self-assessments, team audits, and regulatory compliance documentation.

Can I download this checklist as a PDF?

Yes, this checklist is available as a free PDF download. You can also use it digitally in the POPProbe mobile app for real-time data capture, photo documentation, and automatic reporting.

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